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MLD and a Woman’s Menstrual Cycle (part 1)

(Caution: This month’s blog may be a bit awkward for male readers.) A patient recently came into the office seeking relief from symptoms related to her menstrual cycle. Her primary complaints were bloating and weight gain. She had a wedding coming up and wanted to look her best. Can manual lymph drainage (MLD) help with symptoms related to a woman’s period? Let first look at what occurs during a woman’s cycle.

The Cycle

Every month (if things work like they should), a woman goes through a series of steps through which the body prepares for possible pregnancy. The cycle typically lasts 28 days (but the range varies from 21 to 35 days). And it’s regulated by hormones. (If you’ve read past blogs, you may have learned hormones can cause swelling because of how they influence the permeability of the capillary bed, allowing fluid and proteins to escape the blood stream and enter the tissue space.)

Days 1-5: The period. This is when there is active bleeding as the uterine lining sheds. Hormone levels are lower, especially estrogen.

Symptoms: Cramping, bloating, fatigue, mood changes which subside towards the end.

Days 1-13: Follicular Phase. The pituitary gland releases FSH (follicle-stimulating hormone), stimulating the ovaries to produce follicles. One becomes dominant and matures into an egg. Estrogen increases, helping rebuild the uterine lining. Days 8-14 are the best times to get pregnant as there’s an increased chance the sperm will be present when an egg is released (on day 14), but days 8-19 are a conservative window.

Symptoms: Higher energy, mental clarity, clearer/glowing skin, increased sex drive, higher confidence, cervical mucus becomes clearer, stretchier, and more slippery (like egg whites) to help sperm travel easier as ovulation approaches.

Day 14: Ovulation. A few days before ovulation, there’s a surge in LH (luteinizing hormone) triggering the release of the mature egg from the ovary (ovulation) on day 14. This is the most fertile time; sperm can survive up to 5 days, and the egg lives about 24 hours.

Symptoms: Same as the follicular phase. In addition, the breasts and labia may become more sensitive, tender and/or enlarged.

Day 15-28: Luteal Phase.  If there is no pregnancy, the empty follicle becomes the corpus luteum (Latin for “yellow body”), which secretes progesterone to thicken the uterine lining for possible pregnancy. If that doesn’t happen, the corpus luteum breaks down, progesterone drops and menstruation begins.

Symptoms: If no pregnancy occurs, PMS symptoms occur (the symptoms women usually want relief from).

PMS Symptoms

PMS stands for Premenstrual Syndrome. But there are numerous acronyms that substitute meaning: “Pass My Snacks,” “Prepare to Meet Satan,” “Pardon My Sensitivity,” “Pizza and Mood Swings,” and “Please Make it Stop” are among the contenders. The symptoms of PMS can include bloating, cramps, weight gain, mood swings, fatigue, constipation, headaches, food cravings. They’re caused by the rise and sudden, sharp drop of progesterone when there is no pregnancy. This hormone shift can affect brain chemistry, especially serotonin, which influences mood and emotion. When the changes are extreme or severe, it’s called Premenstrual Dysphoric Disorder.

How can MLD help? Find out next month!

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How Much MLD Pressure?

The past few blog posts have been about manual lymph drainage (MLD) and contraindications. When appropriately used, MLD is a modality that has several health benefits. But that’s only when the technique is properly applied.

MLD is a specialized massage designed to stimulate the lymphatic system and promote the movement of lymph fluid. Effective MLD requires an understanding of lymphatic anatomy and biomechanics. Proper technique is critical, as excessive pressure can compromise the delicate structure of initial lymph capillaries, leading to ineffective drainage or structure damage. These capillaries rest beneath the skin’s surface in the dermis layer where there are blood vessels and nerves.

Lymph Capillary Anatomy

The initial lymph capillaries form the entry point for interstitial fluid (fluid in the tissue space) to enter into the lymphatic system. Unlike blood capillaries, they possess unique structural characteristics that make them highly specialized for fluid uptake:

  1. Endothelial Structure: The walls of initial lymph capillaries consist of a single layer of overlapping endothelial cells, creating valve-like openings that allow fluid entry. (Deeper lymphatic structures contain smooth muscle, but these superficial structures do not.)
  2. Anchoring Filaments: These fine thread-like initial lymph capillaries attach lymphatic endothelial cells to surrounding connective tissue. They play a crucial role in preventing capillary collapse and facilitating fluid movement in response to interstitial pressure changes. Anchoring filament diameter is around 20 to 30 nanometers.3
  3. Diameter and Fragility: Initial lymph capillaries are extremely delicate, with diameters ranging from 10 to 60 microns.5 Their thin walls and flexible structure make them highly responsive but also vulnerable to mechanical stress. (According to Foldi, “A gentle and careful touch is indicated, since the lymph vessels affected by MLD are less than one millimeter in diameter on average. The more superficial, valveless lymph capillaries as well as the precapillary channels are even smaller in diameter.”)4

Why Excessive Pressure in MLD Can Be Harmful

MLD should be performed with light, rhythmic movements to optimize fluid mobilization without causing harm. It’s just enough pressure to stretch the skin and not slide, typically around 20-30 mmHg or less.1 This pressure is significantly lower than typical massage techniques, as the goal is not to manipulate the muscles but to gently stimulate the lymphatic vessels. Applying too much pressure can result in the following complications:

  1. Capillary Compression and Closure: Due to their fragile nature, lymph capillaries can collapse under excessive pressure, preventing fluid entry and impeding drainage.
  2. Damage to Anchoring Filaments: These filaments are highly sensitive to mechanical force. Excessive pressure can rupture them, reducing the efficiency of fluid uptake and leading to localized edema.
  3. Increased Interstitial Pressure: Heavy-handed techniques may inadvertently increase interstitial pressure, pushing fluid back into tissues rather than facilitating its movement into lymphatic capillaries.

(It’s important to note, there are times such as when dealing with fibrosis that this light pressure may need to be firmer.)

Principles of Effective MLD1

To maximize the effectiveness of MLD and protect the integrity of lymphatic structures, practitioners should adhere to the following principles:

  • Gentle, rhythmic movements applied at a rate of about 1/sec, with 5–7 repetitions per area. The pressure is gentle and light (typically 20-30 mmHg or less)2 to ensure the capillaries remain open and receptive to fluid intake. The motions are predominately circular and done to stretch the skin which, in turn, stretches the lymphangion wall and increases lymphangiomotion (the contractions of lymphangions, the deeper lymph vessels which contain smooth muscle).
  • Use of a pressure phase, which promotes movement of fluid in the desired drainage direction, and a pressure-free or relaxation phase, in which a vacuum caused by passive distention of the tissue leads to refilling of the lymph vessels from the periphery (Vodder’s “suction effect”).
  • Directing lymph flow by starting proximally and moving distally. MLD follows a specific sequence, starting with the clearing of proximal areas (nearer to the trunk) to ensure that distal areas (farther from the trunk) can effectively drain. The sequence also follows the anatomical pathways of lymphatic drainage, guiding fluid toward functioning lymph nodes (via normal pathways – or rerouting fluid to healthy pathways when there is damage).
  • Use of slow, repetitive strokes. MLD is most effective when performed with consistent, repetitive motions that mimic the natural pumping action of the lymphatic system. This also creates a relaxation effect.

By understanding the delicate nature of initial lymph capillaries and applying appropriate MLD techniques, therapists can optimize lymphatic function while avoiding potential harm. Proper execution, as described in Dr. Földi and Dr. Vodder’s text, ensures that MLD remains a safe and effective therapy for individuals managing lymphedema and other lymphatic disorders.

References
1 Földi, Michael; Földi, Ethel; Strößenreuther, Cornelia; Kubik, Stefan. Földi’s Textbook of Lymphology: for Physicians and Lymphedema Therapists (German Edition) (pp. 1360-1361). Elsevier Health Sciences. Kindle Edition.
2 Near-infrared fluorescence lymphatic imaging to reconsider occlusion pressure of superficial lymphatic collectors in upper extremities of healthy volunteers. J Lymphology. 2024; 39(4):234-245. doi:10.xxxx/j.lymph.2024.234
3 Schmid-Schönbein GW, Pusateri AE, Yao L. Structural characteristics and functions of lymphatic capillaries. Microcirculation. 2003;10(4):315-328. doi:10.1080/10739680390179253.
4 Földi, Michael; Földi, Ethel; Strößenreuther, Cornelia; Kubik, Stefan. Földi’s Textbook of Lymphology: for Physicians and Lymphedema Therapists (German Edition) (p. 1430). Elsevier Health Sciences. Kindle Edition.
5 Schmid-Schönbein GW. Microlymphatics and lymph flow. Physiol Rev. 1990;70(4):987-1028. doi:10.1152/physrev.1990.70.4.987

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Contraindications to Manual Lymph Drainage: Insights from Foldi’s Textbook of Lymphology (part 3 of 3)

Two months ago, we began a series on contraindications to MLD. This post will continue that topic, citing a few more contraindications.

6. Severe Hypertension

According to Ai, MLD in patients with severe hypertension can increase vascular pressure and potentially trigger hypertensive crises. (I would partly disagree.) MLD commonly lowers blood pressure due to the stimulation of the parasympathetic nervous system. So, MLD would actually benefit patients with hypertension. However, there are a couple considerations.

First, blood pressure should be monitored before and after MLD to ensure it doesn’t drop too low. Second, MLD should be a gentle, light massage. Too much pressure can contribute to vascular damage. This is particularly important in cases of atherosclerosis or vascular disease impacting arteries. Hardened deposits of fat, cholesterol, and other substances that accumulate in the walls of arteries create arterial plaques. These can potentially become unstable (leading to a blood clot) or dislodge and cause emboli. Emboli can block arterial blood flow (leading to problems like a stroke or PE). The neck is frequently used in MLD sequences. Given the location of the carotid arteries, caution should be used.

7. Acute Inflammatory Conditions

Conditions like arthritis or autoimmune diseases (in an acute phase), or other inflammatory processes like gout or bursitis, can benefit from MLD. But not in the acute phase of a flare up. The manual manipulation of the tissues could intensify the inflammatory response or exacerbate pain and swelling. MLD should only be considered after the acute phase of inflammation has resolved. (Otherwise, there is risk of an exacerbation period before improvement.)

I would add, these inflammatory conditions can also benefit greatly from MLD. The benefits include (among others):

  • stimulation of the lymphatic system, helping to remove excess interstitial fluid (the fluid between cells) and waste products from the tissues
  • reducing swelling and fluid retention in inflamed areas by improving drainage
  • modulating the immune response by reducing the inflammatory responses
  • reducing pain by reducing the inflammation and increasing the drainage of inflammatory particles as well as by stimulating the relaxing effect of the parasympathetic system

Conclusion

Manual Lymph Drainage is a powerful therapeutic tool, but it must be applied carefully and selectively. The above contraindications aren’t comprehensive (there are other precautions including those specific to certain body areas). Understanding the contraindications ensures that patients receive appropriate care and prevents unintended complications. Clinicians should always conduct a thorough assessment of the patient’s health history and current condition to determine whether MLD is suitable. By respecting these contraindications, therapists can help ensure that MLD remains a safe and effective intervention for lymphatic and fluid management.

Generated by Ai (with edits by author)

References
Foldi’s Textbook of Lymphology

*****For Medicare garment coverage updates, click here.*****

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Contraindications to Manual Lymph Drainage: Insights from Foldi’s Textbook of Lymphology (part 2 of 3)

Last month, we began a series on contraindications to MLD. This post will continue that topic, citing a few more contraindications.

3. Heart Failure

Patients with heart failure are at risk for fluid overload, and MLD could further strain their cardiovascular system. The technique’s effects on fluid mobilization may overwhelm the heart’s ability to manage the increased fluid load. Foldi underscores the importance of careful evaluation of a patient’s cardiac function before initiating MLD, especially in those with advanced heart conditions. MLD is not appropriate if heart failure isn’t controlled. And it’s not appropriate if the sole reason for swelling is heart failure as that is a medical condition requiring medical intervention (not lymphedema). Patients with combined edema (from heart failure or other organ dysfunction) and lymphedema require extra caution.

4. Renal Insufficiency

Patients suffering from severe renal insufficiency or kidney failure may experience difficulties in fluid regulation. In such cases, MLD could cause fluid retention and exacerbate symptoms like edema or ascites (according to Ai). (My position is that MLD increases lymphatic flow & ultimately cardiovascular return & renal load. But MLD is primarily not done as it would be of no benefit because lymph vessels are already working at maximum capacity due to the dynamic nature of the edema.) Patients with impaired kidney function should be closely monitored, and MLD should be avoided or used with extreme caution in individuals with compromised renal status. Again, patients with combined edema (from renal disease or other organ dysfunction) and lymphedema require extra caution.

5. Thromboembolic Disorders

Deep vein thrombosis (DVT) or other thromboembolic disorders are a significant contraindication for MLD. Manual lymph drainage can increase blood and lymphatic flow, potentially dislodging clots and causing a pulmonary embolism (PE) or other complications. Foldi’s Textbook emphasizes the critical importance of excluding thrombosis prior to MLD treatment and recommends that patients with active DVT or a history of thromboembolic events within 6 months not undergo MLD (with some exception). DVTs in the acute phase are at risk of dislodging & creating a PE which can kill a person. In the subacute phase (which occurs over the next several weeks), there is typically pain, redness and swelling. The body begins to break down the clot in a process known as fibrinolysis, where enzymes dissolve fibrin and other clot components. As this process happens, part of the clot is reabsorbed, while the remaining structure becomes more organized and fibrous. In the chronic phase (month 3-6), the clot typically becomes firm and organized (restructured with scar tissue) and has little risk of dislodging by month 6.

The exception to waiting 6 months is if a person has a filter and/or receives anticoagulation medication. After stabilization with anticoagulant therapy, MLD may be safely resumed after a 2 to 4-week period (if the physician approves MLD).

Generated by Ai (with edits by author)

References
Foldi’s Textbook of Lymphology

*****For Medicare garment coverage updates, click here.*****

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Contraindications to Manual Lymph Drainage: Insights from Foldi’s Textbook of Lymphology (part 1 of 3)

Manual Lymph Drainage (MLD) is a therapeutic technique designed to stimulate the lymphatic system, promoting the movement of lymph and improving the drainage of excess fluid. This technique is widely used for conditions such as lymphedema, post-surgical recovery, and certain inflammatory disorders. However, MLD is not appropriate for all patients. According to Foldi’s Textbook of Lymphology, it is essential to understand specific contraindications to ensure patient safety and prevent complications. Here, we will explore some of these contraindications, providing a deeper understanding of when MLD should be avoided.

1. Acute Infections

One of the primary contraindications to MLD is the presence of acute infections. This includes bacterial, viral, or fungal infections, which could be exacerbated by the increased circulation induced by MLD. The stimulation of lymphatic flow could spread infectious agents through the body, worsening the condition or increasing the risk of sepsis. Conditions such as cellulitis, abscesses, or acute skin infections require medical treatment and should not be treated with MLD until the infection is resolved. Interestingly, the body protects itself against infectious agents by causing lymphangions to spasm. This contraction is part of the body’s attempt to limit the spread of infection or inflammation by slowing down lymph flow and creating a “barrier” effect. When performing MLD properly (which includes gentle, rhythmic strokes), the parasympathetic nervous system (the “rest and digest system”) is reflexively stimulated, causing relaxation and enhancing lymphatic circulation. As a result, these lymphangion spasms can relax, potentially allowing the spread of the infection to other parts of the body.

2. Malignant Diseases (Cancer)

While MLD can be beneficial for some cancer-related issues, it is contraindicated in active cancer or in cases where the patient has metastatic disease. Foldi emphasizes that manual drainage may inadvertently promote the spread of cancer cells, particularly in individuals with untreated or advanced malignancy. The stimulation of lymph flow could potentially facilitate the movement of cancerous cells, thus accelerating metastasis. MLD should not be performed over the affected areas in such cases unless specifically approved by an oncologist.

cancer cells

There is some debate about this in recent times by newer graduating lymphedema therapists. The debate centers around the fact that cancer cells choose whether or not to turn on or off. So, MLD isn’t “causing cancer.” But the caution is that cancer cells spread through one of two ways: blood flow or lymph flow. The concern with MLD during active cancer (particularly over the site of cancer) is that you speed up potential spread of cancer cells by stimulating lymph flow. I always disclose these facts to patients. I require patients with active cancer to sign a waiver if they wish to receive MLD. (Gloves should be worn if chemo is being administered.) In terminal cancer cases, the massage can be especially calming & comforting.

Generated by Ai (with edits by author)

References
Foldi’s Textbook of Lymphology

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Could MLD help Nerve Inflammation or Brain Congestion?

Researchers at Yale are studying the lymphatics discovered in the meningeal dura mater. Anne Eichmann, Professor of Medicine said, “Meningeal lymphatic vessels are potential targets to treat brain diseases.”1 This includes causes of intracranial hypertension like brain injury or stroke according to Foldi.2

Foldi had it going on

Years before Yale’s 2022 research, Foldi had written about this in the Foldi Textbook of Lymphology. In the chapter on lymphostatic diseases, Foldi notes lymphostatic failure can occur in the body’s organs – including the brain. Many people might consider this “lymphedema.” But lymphedema is referring to the lymphostatic condition that affects the skin & tissues. When it’s elsewhere in the body, it’s simply called “lymphostatic failure.” If it affects the nerves, it’s called, “lymphostatic neuropathy.” If it affects the brain, it’s called, “lymphostatic encephalopathy.” Etc. Foldi states, “Any organ requiring lymphatic drainage develops a lymphostatic disease under circumstances of low-output failure or combined [high & low output] failure.”2

What can give rise to congestion surrounding nerves? Inflammation, as occurs in trigeminal neuralgia (cranial nerve V is affected) & Bell’s Palsy (the facial nerve, cranial nerve 7, is affected). Cranial nerve V runs through the dural venous sinus (the cavernous sinus). Cranial nerve 7 passes through the temporal bone. There’s a head & neck MLD sequence that can address this.

On the right is the facial nerve involved in Bells’ Palsy. The picture shows it passing through the temporal bone. The nerve can swell, causing it to be compressed. This leads to the symptoms people experience.

Why direction matters

It’s important to be aware that dural venous sinuses don’t have valves or muscle like regular veins do.  As a result, blood can flow backwards. In fact, most brain veins (except for the larger pial veins) don’t have valves or muscle.3 (Spinal veins are also valveless & muscleless.4)

The Noted Anatomist describes the dural venous sinuses at minute 5 in this video.

The missing valves & muscle in these veins allows them to expand if intracranial pressure rises. But, as The Noted Anatomist states, “Veins that drain the eyes or nasal pages could flow backwards, back into the orbit or nasal area. This could transport infection into the brain.” That’s the downside. MLD may be able to help this backflow caused by congestion.

How MLD could help

Foldi notes that, “Immune deficiency develops in lymphedematous areas. This fact plays an important role in the pathophysiology of lymphostatic diseases.”5 In lymphedema, as inflammation continues, we see the changes characteristic of lymphedema tissue as the disease progresses (skin thickening, fat growth, scarring or fibrosis, skin papules & hyperkeratosis, etc.). Complete decongestive therapy (with MLD being one of the components of CDT) improves this condition by decongesting the tissue. It’s a proven fact that proper MLD speeds up lymphatic flow.6,7,8 Check out the below video of a person receiving leg MLD. It shows the movement of lymph fluid before & after MLD.

If MLD can increase lymph transport, it stands to reason that it could reduce swelling around nerves or congestion in the brain given what we’ve learned about anatomy. Foldi has already suggested that it does. Wolf Lüdemann (physician) treated patients with intracranial pressure due to brain injury using MLD. And the pressure reduced.9 (It’s important to note position can also play a role in intracranial pressure.)

Foldi highlighted patients with recurrent inflammatory nasal congestion & primary lymphedema (which caused dysplasia of the jaw & paranasal sinuses) who were treated with MLD. Their tonsils were often enlarged, leading to mouth-breathing. The kids often have trouble staying awake & concentrating in school. Colds were a common occurrence. MLD improved their symptoms.10

The start of modern MLD

It’s interesting to note that Dr. Emil Vodder (credited with being the founder of MLD) got his start in the south of France treating patients with colds, migraines & sinus problems.11

Conclusion

MLD has potential to help nerve inflammation & conditions causing intracranial pressure through head & neck MLD. In fact, “Földi’s concept of lymphostatic encephalopathy provides both a possible explanation of the wide spectrum of symptoms after these accidents [causing increased brain pressure] and a way to help heal the problems by using MLD.”12

References
1 https://medicine.yale.edu/news-article/the-brains-drainage-system-in-3-dimensions/
2 Földi, Michael; Földi, Ethel; Strößenreuther, Cornelia; Kubik, Stefan. Földi’s Textbook of Lymphology: for Physicians and Lymphedema Therapists (German Edition) (p. 515). Elsevier Health Sciences. Kindle Edition.
3 Hufnagle JJ, Tadi P. Neuroanatomy, Brain Veins. [Updated 2023 Jul 24]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. (https://www.ncbi.nlm.nih.gov/books/NBK546605/#:~:text=Structurally%2C%20the%20veins%20of%20the,a%20circumferential%20smooth%20muscle%20layer)
4 (Green K, Reddy V, Hogg JP. Neuroanatomy, Spinal Cord Veins. [Updated 2023 Jul 24]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. https://www.ncbi.nlm.nih.gov/books/NBK542182/)
5 Földi, Michael; Földi, Ethel; Strößenreuther, Cornelia; Kubik, Stefan. Földi’s Textbook of Lymphology: for Physicians and Lymphedema Therapists (German Edition) (pp. 515-516). Elsevier Health Sciences. Kindle Edition.
6 https://ltstherapy.com/blog/can-mld-slow-cognitive-decline-part-3/
7 Tan IC, Maus EA, Rasmussen JC, et al. Assessment of lymphatic contractile function after manual lymphatic drainage using near-infrared fluorescence imaging. Arch Phys Med Rehabil. 2011;92(5):756-764.e1. doi:10.1016/j.apmr.2010.12.027 (https://pmc.ncbi.nlm.nih.gov/articles/PMC3109491/)
8 https://www.movinglymph.com.au/post/update-on-icg
9 Földi, Michael; Földi, Ethel; Strößenreuther, Cornelia; Kubik, Stefan. Földi’s Textbook of Lymphology: for Physicians and Lymphedema Therapists (German Edition) (p. 716). Elsevier Health Sciences. Kindle Edition.
10 Földi, Michael; Földi, Ethel; Strößenreuther, Cornelia; Kubik, Stefan. Földi’s Textbook of Lymphology: for Physicians and Lymphedema Therapists (German Edition) (p. 712). Elsevier Health Sciences. Kindle Edition.
11 https://vodderschool.com/emil_vodder_life_work_article
12 (Földi, Michael; Földi, Ethel; Strößenreuther, Cornelia; Kubik, Stefan. Földi’s Textbook of Lymphology: for Physicians and Lymphedema Therapists (German Edition) (p. 1844). Elsevier Health Sciences. Kindle Edition.)

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Can MLD Slow Cognitive Decline (Part 3)

The last two months we learned the brain has lymphatics in the outer meningeal layer (which is just beneath the skull). We also learned an accumulation of waste in the CNS is the likely cause of neurological pathology.

The Disease Process

Specifically, two types of waste accumulate in the CNS during this neuropathology:

  1. amyloid beta peptide – a metabolic waste product in the brain created during neuronal activity &
  2. phosphorylated tau protein – tau protein that has become highly phosphorylated & insoluble. That is to say, when multiple phosphate groups are added to its structure, tau can detach from microtubules (the “highways” within neurons) & cause neurofibrillary tangles that block the neuron transport system. This causes cells to die.

To summarize, the accumulation of these waste products leads to inflammation, cell death & the symptoms seen in neurological diseases like Alzheimer’s (a form of dementia), multiple sclerosis, Parkinson’s & traumatic brain injury among others.1 The reason for this waste buildup is a disruption in drainage of fluid from the CNS. How does fluid drain from the CNS?

CNS fluid drainage

Fluid drains from the central nervous system through pathways similar to the rest of the body: veins & lymphatic pathways.2 The brain (cerebrum, cerebellum & brain stem) drain to the arachnoid (middle meningeal layer) & then to the dural venous sinus before emptying into the internal jugular veins.

The dural venous sinuses are formed by the outer dura mater when it separates to form two layers within the dura mater (one that lines the skull & one that continues around brain tissue).

Interesting fact: In Latin, “dura” means tough & “mater” means mother. Your dura mater is a tough mother!

The spinal cord drains to a network of veins along the spinal cord called the vertebral plexuses. This pathway is a bit more complicated.5,6 For example, the cervical (neck) portion drains to the vertebral veins before emptying to the brachiocephalic veins, the subclavian veins, the superior vena cava & the heart.3  Other spinal cord sections drain differently. But all blood eventually drains to either the superior vena cava or the inferior vena cava before entering the heart.

Lymph fluid drainage

In the last couple of months, we also learned that CNS fluid mixes with interstitial fluid before draining to lymph vessels in the outer meningeal layer (the dura mater). From there (focusing on the brain), fluid drains to the cervical lymph nodes in the neck.

Image depicting lymphatic drainage from the head & neck as it returns to the heart.

What CNS drainage & lymphedema have in common

As we’ve already learned, when CNS drainage is disrupted, it causes congestion & the accumulation of amyloid beta peptide & phosphorylated tau protein. This results in inflammation, cell death & the symptoms associated with neurological diseases.

A similar process happens in lymphedema. When lymphatic drainage is disrupted, it causes congestion & the accumulation of the lymphatic load (protein, in particular). This results in inflammation, tissue remodeling & symptoms (swelling, tissue hardening, skin changes, etc.) associated with lymphedema. Conservative treatment is complete decongestive therapy (CDT). One of the components of CDT is manual lymph drainage (MLD). And herein lies a key to the answer of our blog heading: Can MLD Slow Cognitive Decline?

Professor Michael Foldi

A medical doctor, Professor Foldi & his wife (also a physician) have spent years researching, collaborating, teaching, & treating patients with lymphedema. In 1966, Professor Foldi said, “The potential role of the lymphatic system should never be disregarded in any disease of the central nervous system.”7 In the chapter on lymphostatic diseases in the Foldi textbook, Wolf Lüdemann (physician) did a study in 2004 showing the positive influence of MLD on intracranial pressure in severe traumatic brain injury.8 A 2016 article showed cervical & cranial MLD improved intracranial pressure as well as did a 2023 study.9,10

How MLD could impact CNS drainage

Deeper lymph vessels called collectors have components called lymphangions. Lymphangions have a proximal & distal valve as well as muscle that moves lymph through the collectors. “During the systole of the lymphangion, the proximal valve is open and the distal valve is closed. The lymph is pumped into the next lymphangion, which is in its diastole at that moment. “A lymphangion responds to an increased load like the heart.”12 In fact, lymphangions are sometimes referred to “mini-hearts.” When at rest, the lymph flow (per unit of time) is low.  But when lymph flow increases, then the amount of lymph entering a lymphangion also increases. This causes the wall of the lymphangion to be stretched & lymph fluid to be transported. “Stretching the lymphangion wall from the outside through manual lymph drainage has the same effect!”13

Improving neurological conditions like dementia

In closing, MLD impacts the flow of lymphatic fluid. When there is congestion as can be seen in the CNS in neurological conditions like dementia, MLD may very well reduce this congestion by stimulating lymph drainage. In fact, Foldi’s Textbook states, “Fostering the lymphatic drainage of β-amyloid in older persons could prevent its accumulation in the brain, could sustain homeostasis, and could represent a treatment strategy to prevent the decline of mental faculties in Alzheimer’s disease.”11 I would caution that not all MLD is the same. Just because a technique is called “MLD” doesn’t mean it is. See also Guenter Klose’s presentation for LERN.

The original form of MLD (as developed by Dr. Vodder & taught by the Foldi’s) is a two-way stretch of the skin. There are specific characteristics of proper MLD in addition to being a two-way stretch of the skin. These characteristics include being slow (1 second per repetition) & rhythmical among other characteristics.

To learn more about other potential ways to slow cognitive decline, check out this podcast with Dr. Heather Sandison. To learn how microplastics could be contributing to inflammation, check out this interview. You know what else could benefit from MLD? Nerve inflammation. Find out how trigeminal neuralgia & Bell’s Palsy could be improved with MLD next month.

References
1 Bakker EN, Bacskai BJ, Arbel-Ornath M, et al. Lymphatic Clearance of the Brain: Perivascular, Paravascular and Significance for Neurodegenerative Diseases. Cell Mol Neurobiol. 2016;36(2):181-194. doi:10.1007/s10571-015-0273-8; link https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4844641/)
2 Adigun OO, Al-Dhahir MA. Anatomy, Head and Neck: Cerebrospinal Fluid. [Updated 2023 Jul 17]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK459286/
3 https://www.kenhub.com/en/library/anatomy/vertebral-vein
4 https://www.youtube.com/watch?v=WTu31680f6s
5 https://www.physio-pedia.com/Spinal_Cord_Anatomy
6 Green K, Reddy V, Hogg JP. Neuroanatomy, Spinal Cord Veins. [Updated 2023 Jul 24]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. (https://www.ncbi.nlm.nih.gov/books/NBK542182/)
7 Földi, Michael; Földi, Ethel; Strößenreuther, Cornelia; Kubik, Stefan. Földi’s Textbook of Lymphology: for Physicians and Lymphedema Therapists (German Edition) (p. 715). Elsevier Health Sciences. Kindle Edition.
8 Földi, Michael; Földi, Ethel; Strößenreuther, Cornelia; Kubik, Stefan. Földi’s Textbook of Lymphology: for Physicians and Lymphedema Therapists (German Edition) (p. 774). Elsevier Health Sciences. Kindle Edition.
9 Roth C, Stitz H, Roth C, Ferbert A, Deinsberger W, Pahl R, Engel H, Kleffmann J. Craniocervical manual lymphatic drainage and its impact on intracranial pressure – a pilot study. Eur J Neurol. 2016 Sep;23(9):1441-6. doi: 10.1111/ene.13055. Epub 2016 May 30. PMID: 27238738.
10 Esparza WD, Aladro-Gonzalvo AR, Ruíz-Hontangas A, Celi D, Aguirre MB. The Effect of Craniofacial Manual Lymphatic Drainage after Moderate Traumatic Brain Injury. Healthcare (Basel). 2023;11(10):1474. Published 2023 May 18. doi:10.3390/healthcare11101474
11 Földi, Michael; Földi, Ethel; Strößenreuther, Cornelia; Kubik, Stefan. Földi’s Textbook of Lymphology: for Physicians and Lymphedema Therapists (German Edition) (pp. 717-718). Elsevier Health Sciences. Kindle Edition.
12 Földi, Michael; Földi, Ethel; Strößenreuther, Cornelia; Kubik, Stefan. Földi’s Textbook of Lymphology: for Physicians and Lymphedema Therapists (German Edition) (p. 450). Elsevier Health Sciences. Kindle Edition.
13 Földi, Michael; Földi, Ethel; Strößenreuther, Cornelia; Kubik, Stefan. Földi’s Textbook of Lymphology: for Physicians and Lymphedema Therapists (German Edition) (p. 450). Elsevier Health Sciences. Kindle Edition.

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Can MLD Slow Cognitive Decline? (Part 2)

Last month we learned the brain has lymphatic vessels in the outer meningeal layer (the dura mater). Fluid inside the brain (cerebral spinal fluid) mixes with interstitial fluid in the innermost meningeal layer (the pia mater) before draining to the outer dura mater & its lymphatic vessels. When things go awry, dementia enters the picture. How does this occur?

The Glymphatic System

Along the blood vessels in the brain are cells called astrocytes. Astrocytes are a type of glial cell (a specialized WBC that are helpers or support cells for neurons & coat neurons with myelin).1 They come from monocytes & reside in the CNS.

Astrocytes & microglial cells (another type of glial cell in the CNS) aid in nutrition, but they also help with immunity, waste clearance & maintaining homeostasis (just like the lymph system does). The perivascular channels containing these cells were named the “glymphatic system” because of their similarity to lymphatic system function.2,3,4

perivascular channels

The Cause of Dementia & Other Neurological Conditions

Previously, amyloid plaques were thought to be the cause of Alzheimer’s. Instead, they’re likely a by-product of the glymphatic system drainage disruption. More recent research is finding impairment in the glymphatic drainage is the likely cause of many neurological conditions, including dementia & Alzheimer’s (a form of dementia), by allowing a buildup of harmful waste to occur in the brain.  There seem to be two primary culprits.

The Culprits

One culprit is faulty clearance of the fibrillar form of the beta-amyloid protein (an imbalance in the production & clearing of the peptide that comes from the processed amyloid protein, in particular).5,6 Another culprit is faulty clearance of the phosphorylated tau protein.7,8

The Stars of the CNS

Glial cells found in the brain (astrocytes, oligodendrocytes & microglia) can be considered the stars of the CNS because of their important role in preventing inflammation & their job of coating neurons with myelin.9 Myelin is the fatty sheath that surrounds & protects nerve fibers. It allows nerve impulses to travel quickly & efficiently.

diagram showing myelin sheath

Brain inflammation (such as faulty clearance of substances mentioned above) causes this myelin sheath to break down, leading to the symptoms experienced in neurological diseases.10 How could MLD help? Find out in part 3.

References
1 https://my.clevelandclinic.org/health/body/23273-autonomic-nervous-system
2 https://www.nih.gov/news-events/nih-research-matters/new-brain-cleaning-system-discovered
3 https://www.researchgate.net/figure/Outline-of-the-glymphatic-system-This-figure-illustrates-that-perivascular-clearance_fig1_322688508
4 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636982/#:~:text=The%20glymphatic%20system%20is%20a,from%20the%20
central%20nervous%20system
5 https://www.medicalnewstoday.com/articles/if-amyloid-accumulation-is-part-of-normal-aging-what-causes-alzheimers#:~:text=The%20researchers%20showed%20that%20the,journal%20of%20the%20Alzheimer’s%20Association
6 https://www.ncbi.nlm.nih.gov/books/NBK459119/
7 Garland EF, Hartnell IJ, Boche D. Microglia and Astrocyte Function and Communication: What Do We Know in Humans?. Front Neurosci. 2022;16:824888. Published 2022 Feb 16. doi:10.3389/fnins.2022.824888 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8888691/)
8 https://www.nih.gov/news-events/nih-research-matters/lymphatic-vessels-discovered-central-nervous-system#:~:text=The%20lymphatic%20system%20carries%20white,was%20termed%20the%20glymphatic%20system
9 https://my.clevelandclinic.org/health/body/23273-autonomic-nervous-system
10 https://my.clevelandclinic.org/health/body/22974-myelin-sheath

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Can MLD Slow Cognitive Decline? (Part 1)

Until recently, it was thought the brain had no lymphatic vessels. Research in 2012 proved otherwise.

Lymphatics of the Brain

In this study, scientists injected tracer dye into the subarachnoid space of the brains of living mice.

Subarachnoid space showing CSF. Cerebral spinal fluid travels around the brain & spinal cord & in the ventricles of the brain providing nutrients & removing waste.3

The subarachnoid space is found within the membranes (called meninges) that cover the brain & spinal cord.

Meninges

There are three layers of protective meninges. The inner layer is called the pia mater. Between the inner layer & the middle layer (called the arachnoid meningeal layer) is the subarachnoid space that houses the cerebral spinal fluid (& blood vessels). The outside layer of meninges is called the dura mater.

Cervical lymph nodes & CSF

Researchers followed the dye they had injected during their study. They observed that CSF drained from the inner brain (the CNS or central nervous system) to lymphatic vessels in the outer brain (the dura mater meningeal layer) before draining to the cervical lymph nodes in the neck.4 So, this study showed lymphatic vessels were present in the brain – the outer dura mater meningeal layer in mice.1,2 (Turns out, they’re in humans, too, as well as the spinal cord meninges.)4

Perivascular channels

The pia mater meningeal layer contains spaces known as perivascular channels (also called “Virchow-Robin” channels). These channels are created by the space between blood vessel walls & the inner pia mater meningeal layer. Cerebral spinal fluid (CSF) mixes with interstitial fluid (fluid found within the tissue space between cells – the fluid we deal with in lymphedema) continuously within this perivascular space before draining to the lymphatic vessels in the outer dura mater.

Where does dementia come into the picture? Find out next time as we continue to part 2.

References
1 https://www.nih.gov/news-events/nih-research-matters/new-brain-cleaning-system-discovered
2 https://www.nih.gov/news-events/nih-research-matters/lymphatic-vessels-discovered-central-nervous-system#:~:text=The%20lymphatic%20system%20carries%20white,was%20termed%20the%20glymphatic%20system.
3 https://www.nih.gov/news-events/nih-research-matters/new-brain-cleaning-system-discovered
4 Hershenhouse KS, Shauly O, Gould DJ, Patel KM. Meningeal Lymphatics: A Review and Future Directions From a Clinical Perspective. Neurosci Insights. 2019;14:1179069519889027. Published 2019 Dec 31. doi:10.1177/1179069519889027 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176397/#:~:text=They%20demonstrated%20lateral%20branches%20associated%20with%20spinal%20nerves%20and%20blood%20vessels.&text=The%20localization%20of%20the%20lymphatics,nonhuman%20primate%2C%20and%20human%20specimens.&text=Further%20anatomical%20evidence%20for%20this,meningeal%20arteries%20and%20venous%20sinuses.&text=However%2C%20this%20localization%20remains%20an,access%20from%20the%20dura%20mater

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Compression Billing Confusion

We’re resuming our educational blog about lymphedema. And we’re moving on from the last few posts about Medicare’s new coverage of lymphedema supplies & compression … almost. I had a recent incident worth mentioning.

Lymphedema Treatment Act Website

The Lymphedema Treatment Act (LTA) website has a list of durable medical equipment (DME) suppliers for lymphedema compression supplies & garments. It’s a good start, but it’s not entirely accurate. I’ve had a few inquiries from people who saw this business (Lymphedema Therapy Source) listed on the LTA website as a Medicare supplier. While this business just became an approved Medicare DME supplier this month, it can’t provide supplies or compression garments for people in states outside of Texas (not yet, anyway). That’s because most states (if not all) require a business to have a (DME) license in their state. And that usually requires a physical presence in that state.

The LTA advocacy team sent an email in Aug informing readers that Medicare has updated their online supplier search tool to include compression supplies. Unfortunately, Medicare (nor the Lymphedema Treatment Act website) contain an accurate list of businesses that can bill Medicare for lymphedema supplies.

August LTA newsletter. While both Medicare & the LTA lists include DME suppliers, Medicare’s list may not specialize in lymphedema products. And the LTA list may not include DME suppliers that can bill Medicare in your state (or at all).

How to Find a Billing Supplier

If you have insurance other than Medicare, your carrier may provide a list of suppliers for DME that are in-network. But like the Medicare list, they may not specialize in lymphedema products. The takeaway is: You should call before making a trip to visit a supplier to make sure they sell (on site) the item you’re seeking.

Here’s an example. A few weeks ago, a man came to my office building looking for an orthotic (with a doctor’s script in hand). His doctor had sent him to the building because another company (Accentus) is a local DME supplier who showed as in-network with his insurance. What the man didn’t know is the company specializes in diabetic supplies & that particular office is solely composed of backend office staff (i.e. it’s not a storefront). The girls in the office came looking for me assuming I could help him.

While this business can now bill insurance for DME, the specialty is lymphedema. Not orthopedic products like an ankle brace. I was able to read the script, explain the situation, & advise the man he needed to contact his insurance company again for a list of in-network suppliers. He then needed to call those companies to ensure they sold the ankle support he needed.

Conclusion

While it’s terrific that Medicare will now pay for lymphedema compression, treatment supplies & aids thanks to the efforts of the Lymphedema Treatment Act team, the downside is there’s a lot of confusion among beneficiaries as to how to find a supplier who can bill for their DME needs.

(First posted 09/16/24 for Aug.)

Contact Us

309 W. Eldorado Pkwy
Little Elm, Texas 75068-5196
214-422-8265 | 469-579-5034
214-614-9352 fax
info@LTStherapy.com

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